About the Molecular AOP Analyser

The Molecular AOP Analyser is a web-based tool for Key Event enrichment analysis of transcriptomic data in the context of Adverse Outcome Pathways. It enables researchers and regulators to statistically assess which Key Events within an AOP are supported by their experimental gene expression data.

Purpose

Given a differential gene expression dataset and a selected AOP, the tool performs Fisher's exact test enrichment analysis to identify Key Events whose associated gene sets are significantly over-represented among differentially expressed genes. Results are visualised as an interactive AOP network with gene-level expression overlays.

Part of VHP4Safety

This tool is developed as part of the VHP4Safety (Virtual Human Platform for Safety Assessment) project, an initiative to develop a virtual human platform for next-generation risk assessment of chemicals, pharmaceuticals, and other substances.

Data Sources

Key Event gene set mappings are derived from the molAOP Builder platform, which links AOP Key Events to WikiPathways biological pathways. Gene annotations are sourced from WikiPathways.

Contact

For questions, feedback, or collaboration enquiries, please contact the VHP4Safety bioinformatics team or visit the VHP4Safety website.